China (Mainland)
TAT(48-60)
- Min.Order: 1 Milligram
- Payment Terms: T/T
- Product Details
Keywords
- TAT48-60
- HIV - 1 Tat (48 - 60) GRKKRRQRRRPPQ
- GRKKRRQRRRPPQ
Quick Details
- ProName: TAT(48-60)
- Molecular Formula: C70H131N35O16
- Appearance: Whithe powder
- Application: Research
- DeliveryTime: quote
- PackAge: According customer's requirements
- Port: Shanghai
- ProductionCapacity: 1-1000 Gram/Day
- Purity: 95%;98%;99%
- Storage: keep in dry,cool
- Transportation: According customer's requirements
- LimitNum: 1 Milligram
- Moisture Content: <1%
- Residual Solvent: <1%
- Heavy Metal: Null
Superiority
Shanghai Apeptide Co.,Ltd is one of famous-peptide manufacturers in China.
For 10 years we have supplied peptides/API pepitdes/Custom Peptide/ Amino acides/ protein etc...
Our website address: www.apeptides.com/en/
We have amyloid peptides libs and supply high quality\competetive price\best service.
We Supply :
Peptide
Custom pepitdes synthesis
Amino acids/Unusual amino acids
Custom amino acid synthesis
Protein expression
We can do:
Custom Peptide Modifications
o Amidation,C-termainal
o Aldehydes,C-termainal
o Alcohols,C-termainal
o pNA (p-Nitroanilide),C-termainal
o AMC,C-termainal
o AFC,C-termainal
o Cysteamide,C-termainal
o Ester,C-termainal
o N-Alkyl Amides,N-termainal
o Acetylated,N-termainal
o Palmytolyl,N-termainal
o HYNIC,N-termainal
o Biotinylated,N-termainal
o Bromoacetylated,N-termainal
o DOTA，DTPA conjugated,N-termainal
o Formylated,N-termainal
o Myristoylated,N-termainal
o Succinylated,N-termainal
Dye-labeled peptides
AFC, AMC, Lys(Dye), pNA, Rh110
N-terminal Modifications
Bodipy-FL, Cy3, Cy5, Texas Red, 5-Tamra, 5-lodoacetamido fluorescein
Rhodamine 110 and Rhodamine B Luciferin, EDANS
FAM, FITC, MCA, Rox, Sulforhodamine 101, 5-TAMRA
Cyclic peptides
o N -> C or Head to Tail o Disulfide (S-S bond formation) .Trisulfide formation）
o Cyclic-natural peptides
Methylated peptides
o Lys(For),Lys(Me), Lys(Me)2, Lys(Me)3, Arg(Me)2 symmetrical, D-Tyr(Me),D-Tyr(Et)
o Na-Methylated（N-Me-Arg,N-Me-Asp, N-Me-Glu, N-Me-Leu, N-Me-Nle, N-Me-Nva, N-Me-Phe, N-Me-S N-Me-Ser, N-Me-Trp, N-Me-Thr, N-Me-Val）
Other modifications
o BSA, KLH conjugated peptides for antibody production ）
o Phosphoserine, Phosphothreonine, Phosphotyrosine
o Sulfated Tyrosine or Serine
o MAPS (Multiple Antigenic Peptide)
o Glycopeptides
o PEGylation
o Peptidomimetics
Details
Description
HIV-1 TAT (48-60) is a cell-penetrating peptide derived from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way.
In Vitro
Studies show that exogenous Tat protein is able to translocate through the plasma membrane and to reach the nucleus to transactivate the viral genome. The HIV-1 TAT (48-60) peptide, which contains the basic domain of the full length peptide only, retains the full translocation activity and even appears more efficient in terms of nuclear localization when compared with the other active peptides at the standard dose of 1 mM[1]. Cell-penetrating peptides are regarded as promising vectors for intracellular delivery of large, hydrophilic molecules. An apparently endocytotic uptake of HIV-1 TAT (48-60) is observed by confocal laser scanning microscopy[2]. HIV-1 TAT (48-60) induces the formation of rodlike, presumably inverted micelles in DMPC, which may represent intermediates during the translocation across eukaryotic membranes[3].
Molecular Weight
1719.00
Formula
C??H???N??O??
Sequence
Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln
Sequence Shortening
GRKKRRQRRRPPQ
Shipping
Room temperature in continental US; may vary elsewhere
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.